Human Sera
Cayman Chemical Atractylon 50mg
An internal standard for the quantification of spermidine by GC- or LC-MS
Cayman Chemical CeftIbutenhydrate 50mg
An inhibitor of the NF-KB subunit c-Rel inhibits NF-KB DNA binding (IC50 0.1 UM) reduces TNF-a-induced NF-KB activity (IC50 4 UM) decreases proliferation of ABC and GCB DLBCLL cells at 3 UM increases HO-1 expression and ROS production in mitochondria of DLBCL cells but not normal leukocytes increases survival in a mouse model of GVHD at 24 mg/kg every other day beginning eight days after HSCT reduces tumor growth in mouse xenograft models of EBV-induced B cell lymphoma CLL and Richter syndrome
Cayman Chemical DehydroevodIamInhydrochLR 50mg
An inhibitor of USP7 (IC50 424 nM) dose-dependently inhibits USP7-mediated p53 deubiquitination in a cell-free assay (IC50 ~0.8 UM) and in vitro selective for USP7 over a panel of proteases including aspartic serine and metalloproteases (IC50s 10 UM) several cysteine proteases (IC50s 1 and 10 UM) and the deubiquitinating enzymes UCH-L1 (IC50 1 UM) and SENP1 (IC50 10 UM increases p53 levels inhibits proliferation of HCT116 cells (IC50 ~1 UM) induces apoptosis in HCT116 cells
Cayman Chemical Lonurus artmsa Lonurn 100mg
A broad spectrum antifungal agent active against various fungi including Tinea Candida Trichophyton Aspergillus and Epidermophyton has MIC values of 2.5-20 0.63-2.5 31-250 and ≤0.31-0.63 ng/ml for T. mentagrophytes T. rubrum C. albicans and A. fumigatus respectively in broth dilution assays has an in vitro geometric mean MIC value of 2.35 ng/ml against A. terreus prevents mortality in mice and rats with systemic fungal infections effective in eliminating tinea pedis in a guinea pig model when used at a topical concentration of 1
Cayman Chemical SecoIsolarIcIrSnl DIglucs 50mg
An inhibitor of ATG4B inhibits ATG4B cleavage of LC3B-GST (IC50 51 UM) and reduces LC3B lipidation induced by starvation in Saos-2 cells reduces starvation-induced autophagy and prevents autophagic vacuole formation in Saos-2 and MDA-MB-468 cells (100 UM) decreases autophagy in vivo in mouse liver inhibits tumor growth in mouse xenograft model and decreases the number of autophagic vacuoles in osteosarcoma tumors (100 mg/kg)
Cayman Chemical 10methyl9 phenoxycarbonyl 50mg
A natural form of vitamin A a major storage form of vitamin A cytotoxic to HeLa cells alone and when combined with photodynamic therapy when used at concentrations of 1-100 UM decreases tumor volume by 50 in a human gallbladder cancer mouse xenograft model when administered at doses of 1000 or 2500 IU/animal per day for three weeks and when administered prior to tumor implantation
Cayman Chemical OrItavncInphosphate 50mg
A GlyCer synthetase inhibitor an inhibitor of MDCK cell growth in vitro (70 reduction at 20 UM) an inhibitor of DNA synthesis at 3 UM
Cayman Chemical OxtrIphylIn 50mg
A pleuromutilin antibiotic that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation
Cayman Chemical CypermethrIn 50mg
An HDAC1 and HDAC3 inhibitor (IC50s 60 and 50 nM Kis 32 and 5 nM respectively) upregulates frataxin mRNA levels in cultured cells obtained from Friedreichs ataxia patients and in a GAA repeat-based mouse model of Friedreichs ataxia
Cayman Chemical CypermethrIn 100mg
A non-competitive inhibitor of guanylyl and adenylyl cyclases suppresses STa- guanylin- atrial natriuretic peptide- and C-type natriuretic peptide-induced cGMP accumulation in cells (IC50s 3.4-11.2 M) inhibits STa- forskolin- cholera toxin- and isoproterenol-induced chloride efflux in T84 cells suppresses STa-induced liquid secretion in a rabbit intestinal loop model of toxin-induced secretory diarrhea (10 or 50 M)
Cayman Chemical AzoxystrobIn 50mg
An HDAC1 and HDAC3 inhibitor (IC50s 60 and 50 nM Kis 32 and 5 nM respectively) upregulates frataxin mRNA levels in cultured cells obtained from Friedreichs ataxia patients and in a GAA repeat-based mouse model of Friedreichs ataxia
Cayman Chemical DIfenoconazole 100mg
EPA is an W-3 fatty acid abundantly available in marine organisms. It is a poor substrate for COX-1.{1067} EPA has been shown to offer protection against coronary heart disease thrombosis ischemic brain injury scaly dermatitis and some inflammatory diseases.{32208}
Cayman Chemical ChlorpyrIfos-methyl 50mg
A BKCa channel blocker inhibits BKCa single-channel activity in GH3 cells in a concentration-dependent manner from 1-10 M increases respiratory product minute volume in wild-type rats and mice (ED50s 0.1 and 0.5 mg/kg) reverses morphine-induced respiratory depression in rats and cynomolgus monkeys potentiates morphine-induced analgesia in a tail flick assay in rats
Cayman Chemical DegarelIxacetate 50mg
A potent antagonist of NPY receptor Y5 (Kis 1.3 0.79 0.74 and 1.4 nM for human rhesus monkey mouse and rat receptors respectively) 7500-fold selective for Y5 over other NPY receptors and lacks activity in a panel of 180 receptors enzymes and ion channels at concentrations up to 1 M increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner reduces body weight gain in wild-type and diet-induced obese mice when administered at a dose of 30 mg/kg reduces retroperitoneal fat pad weight epididymal and mesenteric fat pad weights leptin levels and food intake in lean mice fed a high-fat diet